WGS of Serratia marcescens: bloodstream infection - SRA

SRX26375935: WGS of Serratia marcescens: bloodstream infection
1 ILLUMINA (NextSeq 1000) run: 178 spots, 51,123 bases, 82,937b downloads

Design: Total genomic DNA was prepared using the KingFisher Cell and Tissue DNA kit (ThermoFisher Scientific, Waltham, MA, USA) or the MagMax DNA Multi-Sample Ultra 2.0 extraction kit (ThermoFisher) on a KingFisher Flex Magnetic Particle Processor (ThermoFisher). DNA libraries were constructed using either the Nextera XT library construction protocol and index kit or the Illumina DNA prep (Illumina, San Diego, CA, USA) with sequencing performed on either a MiSeq Sequencer with a MiSeq Reagent Kit v3 (600 cycles) or a NextSeq 1000 Sequencer using NextSeq1000/2000 P2 Reagents (300 cycles).

Submitted by: Element - JMI Laboratories

Study: Antimicrobial Susceptibility of Enterobacterales causing Bloodstream Infection in United States Medical Centres: Comparison of Aztreonam-Avibactam with Beta-Lactams Active against Carbapenem-Resistant Enterobacterales

PRJNA1171316 • SRP538453 • All experiments • All runs

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Bloodstream infection (BSI) is associated with poor outcomes especially when effective antimicrobial therapy and control of infection source are delayed. As the frequency of Enterobacterales producing metallo-beta-lactamases (MBL) and/or OXA-48-like carbapenemases is increasing in some United States (US) medical centres, effective antimicrobials to treat the infections caused by these organisms are urgently needed. Aztreonam-avibactam is under clinical development for treatment of infections caused by Gram-negative bacteria, including MBL producers. The objective of the study is to evaluate the antimicrobial susceptibility of Enterobacterales causing BSI in US medical centres and compare the activity of aztreonam-avibactam with ceftazidime-avibactam, meropenem-vaborbactam, imipenem-relebactam, cefiderocol, and other antimicrobials used to treat BSI.

Sample:

SAMN44238639 • SRS22899775 • All experiments • All runs

Organism: Serratia marcescens

Library:

Name: 24

Instrument: NextSeq 1000

Strategy: WGS

Source: GENOMIC

Selection: RANDOM

Layout: PAIRED

Runs: 1 run, 178 spots, 51,123 bases, 82,937b

Run	# of Spots	# of Bases	Size	Published
SRR30985002	178	51,123	82,937b	2024-10-14

ID:: 35624532

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